Thermo Fisher Scientific Tankyrase 2 Polyclonal Antibody
Tankyrase 2 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간 및 생쥐 시료에 반응. WB 및 IHC에 사용 가능하며, Wnt 신호전달 및 텔로미어 연구에 적합. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적 유지.
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Thermo Fisher Scientific Tankyrase 2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
| Miscellaneous (PubMed) | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 40–90 of mouse TNKS2 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in human.
- Specificity: TNKS2.
Target Information
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length, and vesicle trafficking.
Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, key components of the beta-catenin destruction complex.
Poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation.
Also mediates poly-ADP-ribosylation of BLZF1, CASC3, and TERF1, contributing to telomere length regulation and proteasome activity stimulation.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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