Thermo Fisher Scientific Itolizumab Humanized Recombinant Human Monoclonal Antibody

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

• Endotoxin level: < 0.01 EU/µg (by LAL method)
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week.
• Store at -20 to -80°C for twelve months from the date of receipt.

Target Information

Itolizumab is a biosimilar that targets CD6.
CD6 (also known as T12) is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia (ALL) cells.
CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse.
CD6-ALCAM mediated cell adhesion is important for T cell proliferation.
CD6 may exert some of its functions via association with CD5, potentially fine-tuning CD5 signaling.
Ligation of CD6 has an antiapoptotic role in chronic lymphocytic leukemia B cells.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.