Thermo Fisher Scientific Olaratumab Recombinant Human Monoclonal Antibody
인간 PDGFR-α에 특이적으로 결합하는 재조합 인간 단일클론 항체. ELISA 등 연구용으로 사용 가능. 단백질 A로 정제된 액상 항체로, 보존제가 포함되지 않음. -20°C에서 장기 보관 가능하며, 반복 동결·해동은 피해야 함.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG1, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Immunogen | Human PDGFRA / PDGFR2 / CD140a |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.22 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911063 |
Product Specific Information
- Endotoxin level < 0.01 EU/µg (LAL method)
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Store at 2–8°C for one week.
- Store at -20 to -80°C for twelve months from the date of receipt.
Target Information
Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-alpha with high affinity and blocks ligand binding. It consists of two heavy chain fragments and two light chain fragments. Studies show that olaratumab, in combination with doxorubicin, significantly reduces cancer cell proliferation and tumor growth. Olaratumab received accelerated approval (as Lartruvo) in October 2016 for initial therapy in adults with certain types of soft tissue sarcoma (STS).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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