Thermo Fisher Scientific CD79a Recombinant Rabbit Monoclonal Antibody (IGA, 3939R)

Applications

Western Blot (WB)

• Tested Dilution: 2–4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

CD79a is a disulphide-linked heterodimer that includes the B29 (CD79b) polypeptide.
It is a B lymphocyte antigen receptor with an antigen-specific surface component (Ig) that associates with Ig-alpha and Ig-beta, essential for B-cell antigen receptor expression and function.
CD79a first appears at the pre-B cell stage and persists until the plasma cell stage, where it is found intracellularly.
It is expressed in most acute leukemias of precursor B cell type, B cell lines, B cell lymphomas, and some myelomas, but not in myeloid or T cell lines.
Diseases associated with CD79a include Agammaglobulinemia 3 and Agammaglobulinemia, Non-Bruton type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.