Thermo Fisher Scientific Phospho-Cardiac Troponin I (Ser23, Ser24) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phosphorylated Cardiac Troponin I (Ser23, Ser24). Suitable for WB and IHC(P). Detects endogenous TNNI3 only when phosphorylated. Supplied as liquid, 1 mg/mL, stored at -20°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNNI3 (Accession P19429), corresponding to amino acid residues around phosphorylated Ser23 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817469 |
Product Specific Information
Antibody detects endogenous levels of TNNI3 only when phosphorylated at Ser23 and Ser24.
Target Information
Cardiac Troponin I (TnI) is a cardiac-specific inhibitory protein that forms a complex with Troponin C (TnC) and Troponin T (TnT) in cardiac muscle.
TnT binds to tropomyosin to form a troponin-tropomyosin complex, anchored by TnI binding to actin within thin filaments.
Calcium binding to TnC induces a structural change, releasing TnI from actin, enabling myosin attachment and muscle contraction.
Measurement of blood TnI and TnT levels serves as a diagnostic indicator of cardiac muscle damage and helps differentiate angina from myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis and mutations in its gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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