
ELK Biotechnology SPOP rabbit pAb
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Product name: | SPOP rabbit pAb |
Alternative Names: | Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1) |
Applications: | WB;IHC |
Recommended Dilutions: | WB 1:500-2000;IHC-p 1:50-300 |
Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human SPOP. AA range:41-90 |
Storage: | Rabbit |
Storage: | -20°C/1 year |
Clonality: | Polyclonal |
Isotype: | IgG |
Concentration: | 1 mg/ml |
Observed Band: | 42kD |
GeneID(Human): | 8405 |
Human Swiss-Prot No: | O43791 |
Cellular localization: | Nucleus . Nucleus speckle . |
Background: | This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008], |
Species Reactivity: | Human;Mouse;Rat |
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