ELK Biotechnology COL25A1 rabbit pAb
COL25A1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간 및 생쥐 시료에 반응하며, 단백질 농도는 1 mg/ml입니다. -20°C에서 1년간 보관 가능합니다.
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제품명
COL25A1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | COL25A1 |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:10000–20000 |
| Immunogen | Synthetic peptide from human protein at AA range: 101–150 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 64 kD |
| Gene ID (Human) | 84570 |
| Human Swiss-Prot No. | Q9BXS0 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Membrane; Single-pass type II membrane protein. After proteolytic cleavage, CLAC is secreted. |
Background
This gene encodes a brain-specific membrane-associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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