ELK Biotechnology HDAC3 (phospho Ser424) rabbit pAb
HDAC3 (phospho Ser424) rabbit pAb는 인산화된 HDAC3 단백질을 검출하기 위한 고특이성 항체입니다. WB, IHC, IF, ELISA에 적용 가능하며, 인간, 마우스, 랫트에서 반응합니다. 핵 및 세포질 내 HDAC3 위치 연구에 유용합니다.
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제품명
HDAC3 (phospho Ser424) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HDAC3 around the phosphorylation site of Ser424 (AA range: 379–428) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| GeneID (Human) | 8841 |
| Human Swiss-Prot No | O15379 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Nucleus, Cytoplasm, Cytoplasm (cytosol).
Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803).
Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595).
배경 정보
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family.
It has histone deacetylase activity and represses transcription when tethered to a promoter.
It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1.
This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis.
This gene is regarded as a potential tumor suppressor gene.
[provided by RefSeq, Jul 2008]
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