Thermo Fisher Scientific FNTB Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, Jurkat, Raji
• Predicted reactivity: Mouse (97%), Rat (98%), Pig (97%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (97%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Eukaryotic cells contain three types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications enable membrane localization of proteins lacking a transmembrane domain.
CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins ending in the CAAX box, where C is cysteine, A is usually an aliphatic amino acid, and X is typically methionine or serine.
The gene for the beta subunit of CAAX farnesyltransferase (FNTB) is located at 14q23–q24, identified by Southern blot hybridization, PCR analyses of human/Chinese hamster somatic cell hybrid lines, and fluorescence in situ hybridization.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.