Thermo Fisher Scientific CUEDC2 Recombinant Rabbit Monoclonal Antibody (003)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal-origin-free formulations
• Broader immunoreactivity due to the larger rabbit immune repertoire

This antibody has specificity for Human CUEDC2.

Target Information

The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation.
CUE domains are present in eukaryotic proteins involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found.

CUEDC2 (CUE domain-containing protein 2) was identified through yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation via the ubiquitin-proteasome pathway.
CUEDC2 also decreases the sumoylation of PR and interacts with IKK-alpha and IKK-beta, reducing NF-kappa-B activation by decreasing IKK activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.