Thermo Fisher Scientific COL1A1 Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 COL1A1 폴리클로날 항체입니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 고순도(>95%)이며 PBS/glycerol buffer에 보존됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific COL1A1 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human COL1A1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803621 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
The COL1A1 gene encodes the pro-alpha1 chain of type I collagen, which forms a triple helix composed of two alpha1 chains and one alpha2 chain. Type I collagen is fibril-forming and abundant in connective tissues such as bone, cornea, dermis, and tendon.
Mutations in COL1A1 are linked to osteogenesis imperfecta (types I–IV), Ehlers-Danlos syndrome (types VIIA and Classical), Caffey Disease, and idiopathic osteoporosis.
Reciprocal translocations between chromosomes 17 and 22 involving COL1A1 and PDGFB genes are associated with dermatofibrosarcoma protuberans, leading to aberrant growth factor expression.
Two transcript variants result from alternate polyadenylation signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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