Thermo Fisher Scientific IL-23 p19 Recombinant Superclonal Antibody (26HCLC)

Applications

• Western Blot (WB): 1–3 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with non-human primate, mouse, and rat based on sequence homology.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.

While functionally similar to polyclonal antibodies—recognizing multiple epitope sites on the target and providing higher detection sensitivity for low-abundance targets—each Superclonal™ antibody has a defined mixture of light and heavy chains, enabling consistent lot-to-lot production and eliminating biological variability.

Note: Formerly referred to as “Recombinant Polyclonal Antibody”; rebranded as “Recombinant Superclonal™ Antibody”. Product performance remains unchanged.

Target Information

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a p19 protein. The p19 subunit alone is biologically inactive. IL-23 interacts with IL-12Rβ1 and an additional receptor subunit, IL-23R, containing a STAT4-binding domain.

IL-23 is secreted by activated dendritic cells in both mice and humans. In mice, IL-23 differs functionally from IL-12—it does not induce significant IFN-γ production but stimulates strong proliferation of memory T cells and promotes IL-17 production. In humans, IL-23 induces proliferation of memory T cells and moderate IFN-γ production compared to IL-12.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.