Thermo Fisher Scientific NEDD4 Polyclonal Antibody
NEDD4 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, IP 등에 사용 가능. 인간, 마우스, 원숭이, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용.
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Thermo Fisher Scientific NEDD4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50 | View 1 publication |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to human NEDD4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 6 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10976819 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains.
It is involved in the degradation pathway of VEGFR-2/KDFR, independent of its ubiquitin-ligase activity.
Acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, analogous to Mdm2 and p53.
Also reported to be involved in viral budding and regulation of epithelial Na⁺ channels, which can lead to arterial hypertension.
NEDD4 protein localizes to the sarcolemmal region of muscle fibers. Increased expression leads to muscle unloading and denervation, along with decreased Notch1 expression, functioning as a down regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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