Thermo Fisher Scientific ISG15 Polyclonal Antibody
ISG15 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 Flow Cytometry에 적합합니다. 인간, 마우스, 비인간 영장류 반응성을 가지며, 항원 친화 크로마토그래피로 정제되었습니다. 바이러스 감염 관련 면역 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View publication |
| Immunohistochemistry (IHC) | - | View publication |
| Immunocytochemistry (ICC/IF) | - | View publication |
| Flow Cytometry (Flow) | 1:200 | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids from human ISG15 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 34 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979338 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other ubiquitin family members, including ubiquitin, SUMO1, SUMO2, SUMO3, and NEDD8.
Target Information
Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection, either via conjugation to target proteins (ISGylation) or as a free protein. It is secreted from monocytes in response to type I interferons and promotes NK-cell proliferation and non-MHC-restricted cytotoxicity.
ISG15 synthesis is stimulated by IFN-α, IFN-β, or IFN-ω, but not IFN-γ. Expression is also induced by overexpression of interferon regulatory factors and by influenza B virus.
ISG15 is secreted by monocytes, T-lymphocytes, B-lymphocytes, fibroblasts, and epithelial cells. Its activity in enhancing NK cell proliferation and inducing IFN-γ from T cells suggests a role in amplifying the immunomodulatory effects of interferons.
Mutations in the ISG15 gene can result in Immunodeficiency 38, with basal ganglia calcification (IMD38).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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