Thermo Fisher Scientific ISG15 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with other ubiquitin family members, including ubiquitin, SUMO1, SUMO2, SUMO3, and NEDD8.

Target Information

Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection, either via conjugation to target proteins (ISGylation) or as a free protein. It is secreted from monocytes in response to type I interferons and promotes NK-cell proliferation and non-MHC-restricted cytotoxicity.
ISG15 synthesis is stimulated by IFN-α, IFN-β, or IFN-ω, but not IFN-γ. Expression is also induced by overexpression of interferon regulatory factors and by influenza B virus.
ISG15 is secreted by monocytes, T-lymphocytes, B-lymphocytes, fibroblasts, and epithelial cells. Its activity in enhancing NK cell proliferation and inducing IFN-γ from T cells suggests a role in amplifying the immunomodulatory effects of interferons.
Mutations in the ISG15 gene can result in Immunodeficiency 38, with basal ganglia calcification (IMD38).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.