Thermo Fisher Scientific Human CCL2 (MCP-1) Recombinant Protein, PeproTech
인간 CCL2(MCP-1) 재조합 단백질로, 인간 단핵구의 화학유인 활성 평가에 사용. E. coli 발현 시스템에서 생산되며 ≥98% 순도 확보. 염증 및 면역 조절 연구용으로 적합. 실온 배송, -20°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| ELISA | Assay-dependent | View 20 publications |
| Functional Assay | Assay-dependent | View publication |
| In vitro Assay | - | View 110 publications |
| Competition Assay | - | View 1 publication |
| Miscellaneous PubMed | - | View 15 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Bacteria, Dog, Hamster, Human, Mouse, Non-human primate, Pig, Protozoa, Rat |
| Expression System | E. coli |
| Amino Acid Sequence | QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT |
| Molecular Weight | 8.6 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Chemoattracts human monocytes at 10.0–100.0 ng/ml concentration range |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues, including four highly conserved cysteine residues present in CC chemokines.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are secreted proteins involved in immunoregulatory and inflammatory processes.
The protein encoded by this gene is structurally related to the CXC subfamily of cytokines, characterized by two cysteines separated by a single amino acid.
This cytokine exhibits chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It is implicated in diseases with monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis.
It binds to chemokine receptors CCR2 and CCR4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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