Thermo Fisher Scientific CD3 Recombinant Mouse Monoclonal Antibody (PD01-43)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive control: Jurkat cell lysates, human tonsil tissue
• Predicted band size: 23 kDa
• Subcellular Location: Cell membrane

Target Information

The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits (CD3 gamma, CD3 delta, CD3 epsilon, and CD3 zeta). These subunits are structurally related members of the immunoglobulin superfamily encoded by genes on human chromosome 11.

CD3 components have long cytoplasmic tails that associate with signal transduction molecules, mediated by a double tyrosine-based motif. CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation. The CD3 antigen is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells. Decreased T lymphocyte percentages may occur in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.