Thermo Fisher Scientific CD74 Recombinant Mouse Monoclonal Antibody (PDM0-22)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive control: Human B-cell lymphoma tissue, human tonsil tissue, LOVO, Daudi cell lysate, Raji cell lysate
• Predicted band size: 33 kDa
• Subcellular Location: Endoplasmic reticulum membrane, trans-Golgi network, cell membrane, lysosome, endosome

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail. DRA lacks polymorphisms in the peptide binding region and serves as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5. The beta chain contains polymorphisms determining peptide binding specificity.

HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes. The human MHC class II molecules (DR, DQ, DP loci) bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.