Thermo Fisher Scientific Phospho-Chk1 (Ser286) Polyclonal Antibody
Chk1 단백질의 Ser286 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 액상 형태로 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CHEK1 (Accession O14757), corresponding to amino acid residues around phosphorylated Ser286 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816163 |
Product Specific Information
Antibody detects endogenous levels of Chk1 only when phosphorylated at Serine 286.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. It functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, whereas normal cells remain arrested in the G1 phase. CHK1 inhibitors can therefore enhance the efficacy of DNA damaging agents in cancer cells, making Chk1 an attractive therapeutic target, especially since approximately 50% of all human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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