Thermo Fisher Scientific CCL5 (RANTES) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Rhesus Monkey (100%), Guinea pig (100%).
• Positive Control: RANTES transfected 293T cell.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes.
The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide.

CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils.
This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5, and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
Alternative splicing results in multiple transcript variants that encode different isoforms.
Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.