Thermo Fisher Scientific Fumarase Monoclonal Antibody (GT7612)
Fumarase 단백질을 인식하는 Mouse monoclonal antibody(GT7612)로, Western blot 및 Immunocytochemistry에 적합합니다. Human, Mouse, Rat에 반응하며, Protein G로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT7612 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Fumarate hydratase (sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735188 |
Product Specific Information
- Positive Control: 293T, A431, HeLa, HepG2, mouse liver, rat liver
- Predicted Reactivity: Zebrafish (90%), Pig (98%), Chicken (91%), Sheep (99%), Chimpanzee (99%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (Krebs) cycle and catalyzes the formation of L-malate from fumarate. It exists in both cytosolic and mitochondrial forms, differing by the translation start site. The mitochondrial form loses its N-terminal extension to generate the same form as in the cytoplasm. It functions as a homotetramer and is similar to thermostable class II fumarases. Mutations in this gene can cause fumarase deficiency, leading to progressive encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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