Thermo Fisher Scientific Cactin Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse

Target Information

Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidence shows that overexpression of Cactin suppresses TLR-induced activation of NF-κB and interferon-regulatory factor transcription factors, as well as induction of TLR-responsive genes. It is also reported that Cactin interacts with IκB-like protein and targets other proteins encoded by genes in the MHC Class III region of chromosome 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.