Thermo Fisher Scientific CD44 Monoclonal Antibody (OTI2E3), Biotin, TrueMAB
인간 CD44 단백질을 인식하는 마우스 단클론 항체로, Biotin으로 표지된 TrueMAB 형식입니다. ELISA 및 Luminex 분석에 사용 가능하며, 고순도 친화 크로마토그래피로 정제되었습니다. 세포 표면 CD44 관련 연구용으로 적합합니다.
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Applications
ELISA (ELISA)
- Tested Dilution: 1:250–1:1,000
Luminex (LUM)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E3 |
| Immunogen | Full length human recombinant protein of human CD44 produced in HEK293T cell |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.
CD44 functions as a receptor for hyaluronic acid (HA) and plays roles in cell-cell interactions, adhesion, and migration. It is involved in lymphocyte activation, recirculation, and homing. CD44 expression may be up-regulated in certain carcinomas, potentially linked to metastatic potential.
CD44 is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 in response to stimulation.
Transcripts of the CD44 gene undergo complex alternative splicing, generating multiple functionally distinct isoforms. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be implicated in tumor metastasis formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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