Thermo Fisher Scientific PCNA Monoclonal Antibody (OTI1H10), Biotin, TrueMAB
인간 PCNA 단백질을 인식하는 Biotin-conjugated mouse monoclonal antibody. ELISA 및 Luminex 분석에 적합하며, 0.5 mg/mL 농도의 액상 형태로 제공. 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 보장. 연구용으로만 사용 가능.
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Applications
ELISA (ELISA)
- Tested Dilution: 1:250–1:1,000
Luminex (LUM)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H10 |
| Immunogen | Full length human recombinant protein of human PCNA produced in HEK293T cells |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Available Formats
Target Information
PCNA (Proliferating Cell Nuclear Antigen)
PCNA is essential for DNA replication and plays a key role in DNA excision and mismatch repair pathways. It binds to p21, Fen1, XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA serves as a marker for proliferating cells and is useful in assessing tumor proliferation status. It is primarily nuclear, acting as a cofactor for DNA polymerase delta, forming a homotrimer to enhance leading strand synthesis. Upon DNA damage, PCNA undergoes ubiquitination and participates in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been identified, and pseudogenes exist on chromosome 4 and the X chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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