Thermo Fisher Scientific CD86 (B7-2) Monoclonal Antibody (IL-A190), FITC
소, 수지상세포 및 활성화된 B세포에서 발현되는 CD86 항원을 인식하는 단클론 항체. FITC 결합 형식으로 유세포분석(Flow Cytometry)에 적합. 단백질 A 정제, PBS + 1% BSA 완충액, 4°C 보관. 연구용 한정 제품.
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Applications
- Flow Cytometry (Flow): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL-A190 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Protect from light. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745408 |
Additional Formats
Product Specific Information
Mouse anti-Bovine CD86 antibody, clone IL-A190, recognizes the bovine CD86 cell surface antigen, which is expressed by dendritic cells, activated macrophages, and activated B cells.
Target Information
CD86 is one of two ligands (the other being CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation. In the absence of sufficient co-stimulation involving CD86/CD80, antigen presentation can induce tolerance.
CD86 is a type I membrane protein and a member of the immunoglobulin superfamily. It binds to CD28 and CTLA4 on T cells, providing positive (CD28) or negative (CTLA4) regulation of T-cell activation.
Alternative splicing results in two transcript variants encoding different isoforms. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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