Thermo Fisher Scientific IL2RB Monoclonal Antibody (OTI5A5), TrueMAB
Human IL2RB 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western blot에 적합. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 버퍼에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A5 |
| Immunogen | Human recombinant protein fragment (aa 27–240) + Mouse FC of human IL2RB produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and present in three forms:
- Low affinity form: alpha subunit monomer, not involved in signal transduction
- Intermediate affinity form: alpha/beta heterodimer
- High affinity form: alpha/beta/gamma heterotrimer
Both intermediate and high affinity forms participate in receptor-mediated endocytosis and mitogenic signal transduction. The CD122 gene encodes the beta subunit, a type I membrane protein.
Dysfunction of CD122 is associated with oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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