
Thermo Fisher Scientific ATXN10 Polyclonal Antibody
ATXN10 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 검증됨. 인간에 반응하며, 다양한 세포주에서 양성 대조로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품으로, 연구용으로 적합.
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- PA528248
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–393 of Human ATXN10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.78 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545724 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, U87-MG, SK-N-SH, IMR32, SK-N-AS
- Predicted reactivity: Mouse (82%), Rat (85%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (87%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and varying degrees of signs from other components of the nervous system.
A commonly accepted clinical classification (Harding, 1993) divides ADCAs into three groups based on associated symptoms such as brainstem signs or retinopathy:
- ADCA I: Pyramidal and extrapyramidal symptoms, ophthalmoplegia
- ADCA II: Presence of retinopathy
- ADCA III: Absence of associated signs
Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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