Thermo Fisher Scientific ATXN10 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, HeLa, HepG2, U87-MG, SK-N-SH, IMR32, SK-N-AS
• Predicted reactivity: Mouse (82%), Rat (85%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (87%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and varying degrees of signs from other components of the nervous system.
A commonly accepted clinical classification (Harding, 1993) divides ADCAs into three groups based on associated symptoms such as brainstem signs or retinopathy:

• ADCA I: Pyramidal and extrapyramidal symptoms, ophthalmoplegia
• ADCA II: Presence of retinopathy
• ADCA III: Absence of associated signs

Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.