Thermo Fisher Scientific CCL19 Monoclonal Antibody (OTI4F3), TrueMAB
인간 CCL19 단백질(아미노산 22-98)을 인식하는 Mouse IgG1 단일클론 항체. IHC(P)에서 1:150 희석으로 사용 가능. 무보존제, 동결건조 형태로 제공되며 연구용으로 적합. CCL19/CCR7 경로 연구에 활용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4F3 |
| Immunogen | Human recombinant protein fragment (aa 22–98 of human CCL19) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve ~1 mg/mL antibody concentration.
- For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
CCL19, also known as MIP-3β (Macrophage Inflammatory Protein 3 beta), is a member of the CC chemokine subfamily. It shares 32% amino acid sequence homology with CCL21 and is expressed mainly by stromal cells in T cell-rich zones of lymph nodes.
CCL19 and CCL21 mediate homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs, playing roles in T cell priming, activation, and lymphocyte recruitment to inflamed tissue.
Both signal via the CCR7 receptor, expressed on T cells and mature dendritic cells. While both bind CCR7 with equal affinity, only CCL19 binding induces receptor desensitization and internalization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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