Thermo Fisher Scientific Nephrin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Despite its predicted molecular weight, Nephrin often migrates at a lower molecular weight in SDS-PAGE.
A suggested positive control is mouse kidney tissue lysate.
PA5-20330 can be used with blocking peptide PEP-0450.

Target Information

Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end-stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss.
Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2. Nephrin is a podocyte protein that constitutes a major component of the slit diaphragm, especially in the foot process.
Nephrin, a cell adhesion molecule, plays a crucial role in maintaining the glomerular filtration barrier. Mutations in the Nephrin gene reportedly lead to congenital nephrosis.
Podocin, Nephrin, and alpha Actinin 4 are identified in congenital and experimental models of proteinuria. Nephrin’s anti-apoptotic activity in the podocyte slit diaphragm is believed to be associated with VEGF signaling.
Nephrin contributes to the development and function of the kidney glomerular filtration barrier and may anchor the podocyte slit diaphragm to the actin cytoskeleton.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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