Thermo Fisher Scientific SARS-CoV-2 Spike Protein (S1/S2) Monoclonal Antibody (bcb02)
SARS-CoV-2 Spike Protein(S1/S2)을 인식하는 단클론 항체로, Western blot, ELISA, 중화시험에 사용 가능. 인간 IgG 형식의 비접합 항체이며, Protein A 정제 및 고순도(>95%) 제품. 연구용으로 SARS-CoV-2 RBD 및 ACE2 결합 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| ELISA (ELISA) | Assay-dependent | 1 publication |
| Neutralization (Neu) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Published species | Mouse |
| Host / Isotype | Human / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | bcb02 |
| Immunogen | Synthetic peptide corresponding to SARS-CoV-2 Spike Protein (S-ECD/RBD) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.2 |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866561 |
Product Specific Information
- Purity: Greater than 95% as determined by reducing SDS-PAGE
Target Information
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), also known as 2019-nCoV, causes illnesses ranging from mild cold-like symptoms to severe respiratory distress and death.
The Spike (S) protein of SARS-CoV-2 is crucial for viral attachment, fusion, and entry, making it a key target for antibody, inhibitor, and vaccine development.
The receptor-binding domain (RBD, S-RBD) in the S1 subunit binds strongly to human and bat ACE2 receptors, showing higher affinity than that of SARS-CoV.
S1 contains the RBD responsible for ACE2 binding, while S2 mediates membrane fusion.
The full-length SARS-CoV-2 S protein is 1273 amino acids long, including:
- Signal peptide: residues 1–13
- S1 subunit: residues 14–685
- S2 subunit: residues 686–1273
The S-ECD represents the extracellular domain of the Spike protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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