Thermo Fisher Scientific Cathepsin A Polyclonal Antibody

Thermo Fisher Scientific Cathepsin A Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).

Target Information

The cathepsin family of proteolytic enzymes includes several diverse classes of proteases:

• Cysteine proteases: Cathepsins B, L, H, K, S, and O
• Aspartyl proteases: Cathepsins D and E
• Serine proteases: Cathepsin G

Cathepsins function in cellular metabolism, peptide biosynthesis, and protein degradation.
Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with β-galactosidase (β-gal) and α-neuraminidase (Neu1).
It protects β-gal and Neu1 from intralysosomal proteolysis.
Deficiencies in cathepsin A lead to deficiencies in β-gal and Neu1.
The gene encoding human cathepsin A maps to chromosome 20q13.12.
Mutations in this gene cause galactosialidosis, a lysosomal storage disorder resulting from β-gal and Neu1 deficiencies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.