Thermo Fisher Scientific PDCD4 Recombinant Rabbit Monoclonal Antibody (JA80-83)
PDCD4 단백질을 인식하는 토끼 단클론 항체로, Western blot, IHC, ICC, Flow Cytometry 등에 적합. 인간 및 생쥐 시료 반응성. 핵 및 세포질에서 발현 확인용. Protein A 정제 및 1 mg/mL 농도의 액상 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA80-83 |
| Immunogen | Synthetic peptide within human PDCD4 (aa 425–469) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4 °C short term. For long term, store at −20 °C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2911614 |
Product Specific Information
- Positive Control: A431, PC-3M, human tonsil tissue, human prostate tissue, human breast cancer tissue, mouse colon tissue, MCF-7
- Subcellular Location: Nucleus, Cytoplasm
Target Information
Apoptosis, also known as programmed cell death, plays a major role in development and normal tissue turnover as well as tumor formation. During apoptosis, expression patterns of numerous genes are altered. One such gene is programmed cell death protein 4 (PDCD4), a tumor suppressor whose expression is lost in carcinomas of breast, colon, lung, and prostate.
PDCD4 can bind and inhibit the helicase activity of eukaryotic translation initiation factor 4A and suppress AP-1–mediated transcriptional activation. The kinase Akt regulates PDCD4 by phosphorylation, reducing its ability to interfere with AP-1–responsive promoter transactivation. Two isoforms of PDCD4 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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