Thermo Fisher Scientific TNNI3 Monoclonal Antibody (OTI8G8), TrueMAB
인간 TNNI3 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot 및 IHC(P) 적용 가능. 액상 형태로 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. 심근 손상 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8G8 |
| Immunogen | Recombinant protein expressed in E. coli corresponding to amino acids 1–210 of human TNNI3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cardiac Troponin I (TNNI3) is an integral inhibitory protein in cardiac muscle, forming a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit binds to tropomyosin, forming a troponin-tropomyosin complex anchored by TnI binding to actin within thin filaments. When calcium binds to TnC, the inhibitory region of TnI is released, enabling myosin attachment and muscle contraction. Measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, useful for differentiating angina from myocardial infarction. Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro. Mutations in the TNNI3 gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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