Thermo Fisher Scientific TAOK1 Polyclonal Antibody
TAOK1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ELISA에 사용 가능. 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS 버퍼에 0.1% sodium azide 포함, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Bovine, Dog, Chicken, Horse, Hamster, Human, Mouse, Non-human primate, Pig, Rabbit, Rat, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from C-Terminus of human TAOK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550534 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Dog, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Platypus, Xenopus (100%); Zebrafish (88%). - Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.
Target Information
TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs).
It activates MEK3, implicating TAOK1 in the regulation of stress-responsive MAP kinase pathways.
Also known as MARKK, TAOK1 regulates mitotic progression, chromosome congression, and checkpoint-induced anaphase delay.
It participates in p38/MAPK14 stress-activated MAPK cascades, DNA damage responses, and cytoskeleton stability regulation.
TAOK1 phosphorylates MAP2K3, MAP2K6, and MARK2, acting as an activator of the p38/MAPK cascade and a regulator of apoptosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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