Thermo Fisher Scientific PIP5K1C Polyclonal Antibody
PIP5K1C 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 시료에 반응하며, PBS와 50% glycerol로 구성된 액상 형태입니다. 친화 크로마토그래피로 정제되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PIP5K1C (Accession O60331), corresponding to amino acid residues R304–Y354. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900395 |
Product Specific Information
Antibody detects endogenous levels of total PIP5K1C.
Target Information
PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase 1 gamma) is a lipid kinase that phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate.
It is localized at synapses and involved in endocytosis and cell migration.
PIP5K1C associates with β-catenin and enhances its activity downstream of growth factor stimulation, promoting nuclear import and transcriptional activity.
Deficiency of PIP5K1C impairs neutrophil recruitment due to adhesion defects, regulating adhesion via RhoA GTPase and integrin activation by chemoattractants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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