Thermo Fisher Scientific beta-2 Adrenergic Receptor Polyclonal Antibody

Applications and Tested Dilution

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Product Specifications

Product Specific Information

• Recommended positive controls: HepG2, PC-12
• Predicted reactivity: Rhesus Monkey (100%)
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine.
Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family.
Nine receptor subtypes have been identified thus far, including:

• Three alpha-1 AR subtypes (1A/D, 1B, 1C)
• Three alpha-2 ARs (2A, 2B, 2C)
• Three beta AR subtypes (1, 2, 3)

ARs participate in the onset or maintenance of several disease states, including:

• Hypertension
• Cardiac dysfunction (congestive heart failure, ischemia, arrhythmias)
• Diabetes
• Glaucoma
• Depression
• Impotence

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.