Thermo Fisher Scientific ACVRL1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, 293T mem, HepG2, HepG2 mem, BCL-1
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands.
ACVRL1, similar to other type 1 receptors, has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich region (GS domain) preceding the kinase domain, and a short C-terminal tail.
Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2.
Mutations in ACVRL1 have also been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.