Thermo Fisher Scientific WNT4 Recombinant Rabbit Monoclonal Antibody (HL1889)
WNT4 단백질을 표적하는 토끼 단클론 항체로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. 인간 및 제브라피시에 반응하며, HEK293 세포에서 발현된 재조합 항체입니다. 단백질 A로 정제되었으며, PBS 용액 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 | — |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | — |
| Immunocytochemistry (ICC/IF) | Assay-dependent | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL1889 |
| Immunogen | Recombinant fragment of human Wnt4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092441 |
Target Information
The WNT gene family encodes secreted signaling proteins involved in oncogenesis and developmental processes such as cell fate regulation and embryonic patterning.
WNT4 is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein with 98% amino acid identity to mouse and rat Wnt4.
WNT4 and a nuclear receptor known to antagonize the testis-determining factor act together to control female development and prevent testes formation.
Additionally, WNT4, WNT2, and WNT7B may be associated with abnormal proliferation in breast tissue.
Mutations in WNT4 can cause Rokitansky-Kuster-Hauser syndrome and SERKAL syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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