Thermo Fisher Scientific MAP2K4 Recombinant Rabbit Monoclonal Antibody (HL1888)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

Immunocytochemistry (ICC/IF)

Assay-dependent

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1888

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SEK1/MKK4. The exact sequence is proprietary. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MAP2K4,uniProtId:P45985-1,ncbiNodeId:9606,antigenRange:1,antigenLength:399,antigenImageFileName:MA5-50343_MAP2K4_P45985-1_Rabbit.svg,antigenImageFileNamePDP:MA5-50343_MAP2K4_P45985-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3093773

Target Information

MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.