Thermo Fisher Scientific FGFR4 Recombinant Rabbit Monoclonal Antibody (2C4E1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2C4E1

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 700-802 of human FGFR4 (P22455). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FGFR4,uniProtId:P22455-1,ncbiNodeId:9606,antigenRange:700-802,antigenLength:802,antigenImageFileName:MA5-42915_FGFR4_P22455-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42915_FGFR4_P22455-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912056

Product Specific Information

Positive test controls include: HepG2, MCF7, Raji, Mouse lung. The target is usually found in the following locations: Cell membrane, Cytoplasm, Endoplasmic reticulum, Endosome, Secreted, Single-pass type I membrane protein.

Immunogen sequence: SLLREGHRMD RPPHCPPELY GLMRECWHAA PSQRPTFKQL VEALDKVLLA VSEEYLDLRL TFGPYSPSGG DASSTCSSSD SVFSHDPLPL GSSSFPFGSG VQT

Target Information

FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.