Thermo Fisher Scientific PTX3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PTX3. Recombinant protein control fragment (Product #RP-104184). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PTX3,uniProtId:P26022-1,ncbiNodeId:9606,antigenRange:322-381,antigenLength:381,antigenImageFileName:PA5-64410_PTX3_P26022-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64410_PTX3_P26022-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646143

Product Specific Information

Immunogen sequence: GFDETLAFSG RLTGFNIWDS VLSNEEIRET GGAESCHIRG NIVGWGVTEI QPHGGAQYVS

Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 90%.

Target Information

Pentraxins are a protein superfamily that is characterized by a cyclic multimeric structure. Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of long pentraxins, which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells. Secretion of Ptx3 in adipose cells can be induced by TNF. Ptx3 is also involved in amplification of inflammatory reactions and regulation of innate immunity. The human PTX3 gene maps to chromosome 3q25.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.