Thermo Fisher Scientific EXOSC10 Polyclonal Antibody
Thermo Fisher EXOSC10 Polyclonal Antibody는 인간 EXOSC10 단백질을 인식하는 토끼 IgG 항체로, IHC 및 ICC/IF 실험에 적합합니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PM-Scl. Recombinant protein control fragment (Product #RP-94455). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645699 |
Product Specific Information
Immunogen sequence:
FAHPYQYELN HFTPADAVLQ KPQPQLYRPI EETPCHFISS LDELVELNEK LLNCQEFAVD LEHHSYRSFL GLTCLMQIST RTEDF
Highest antigen sequence identity to the following orthologs:
- Mouse: 86%
- Rat: 89%
Target Information
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome have autoantibodies to a nuclear/nucleolar particle termed PM-Scl.
Exosome component 10 (EXOSC10), also known as autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients.
EXOSC10 is strongly enriched in the nucleolus, with a small amount found in the cytoplasm, supporting the existence of a nucleolar RNA exosome complex form.
As a putative catalytic component of the RNA exosome complex with 3′→5′ exoribonuclease activity, EXOSC10 participates in various cellular RNA processing and degradation events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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