Thermo Fisher Scientific RIM2 Polyclonal Antibody
RIM2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC에 적합. 사람, 생쥐, 랫트 반응성. 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장. 신경전달 관련 단백질 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the N-terminal region of mouse Rab3-interacting molecule 2 (RIMS2, RIM2) conjugated to an immunogenic carrier protein. The peptide is homologous in rat and human. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: RIM2.
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins essential for neuronal transmission and plasticity. Rim1 and Rim2 show overlapping but distinct expression patterns in the brain. Deletion of both genes in mice leads to postnatal mortality due to impaired neurotransmitter release. Synapses lacking RIM proteins can release neurotransmitters but fail to respond to normal Ca²⁺ triggers. RIM2 acts as an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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