Thermo Fisher Scientific AKR1C2 Polyclonal Antibody
AKR1C2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, ICC, ELISA 등에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 친화 크로마토그래피로 정제된 액상 제품입니다. 연구용 전용 시약입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–323 of human AKR1C2 (NP_9953171) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.08 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804513 |
Product Specific Information
Immunogen sequence:
MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEAVKL AIEAGFHHID SAHVYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA MEKCKDAGLA KSIGVSNFNH RLLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY
Positive Samples: HT-29, A549, Mouse liver
Cellular Location: Cytoplasm
Target Information
DD1 is also designated AKR1C1, DDH or DDH1, while DD2 can be designated AKR1C2, dDD, BABP or DDH2.
AKR1C3 and 3 alpha-HSD are alternate designations for human DD3 (AKR1C18 in rodents), while DD4 can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents).
DD1 and DD2 are 20 alpha-HSDs, whereas DD3 and DD4 are 3 alpha-HSDs.
These human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics such as polycyclic aromatic hydrocarbons, pesticides, and steroid hormones, and catalyze the reduction of ketone-containing drugs using NADH or NADPH as cofactors.
The 20 alpha-HSD catalyzes the conversion of Progesterone to its inactive form, 20 alpha-hydroxyprogesterone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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