Thermo Fisher Scientific MULT1 (NKG2D Ligand) Polyclonal Antibody
Thermo Fisher Scientific의 MULT1 (NKG2D Ligand) Polyclonal Antibody는 Western blot, IHC, ELISA에 적합한 Rabbit IgG 항체로, Human 및 Mouse 시료에 반응합니다. Affinity Chromatography로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 26–216 of human ULBP1 (NP_079494.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 7.06 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804517 |
Product Specific Information
- Immunogen sequence:
GWVDTHCLCY DFIITPKSRP EPQWCEVQGL VDERPFLHYD CVNHKAKAFA SLGKKVNVTK TWEEQTETLR DVVDFLKGQL LDIQVENLIP IEPLTLQARM SCEHEAHGHG RGSWQFLFNG QKFLLFDSNN RKWTALHPGA KKMTEKWEKN RDVTMFFQKI SLGDCKMWLE EFLMYWEQML DPTKPPSLAP G - Positive Samples: Raji
- Cellular Location: Cell membrane, Endoplasmic reticulum, GPI-anchor, Lipid-anchor
Target Information
ULBP1 is the ligand for the NKG2D receptor, along with ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, leading to cytokine and chemokine production. Binding of ULBP ligands to NKG2D induces calcium mobilization and activation of JAK2, STAT5, ERK, and PI3K/Akt pathways.
In CMV-infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16, which blocks interaction with NKG2D, allowing viral immune evasion. UL16 also retains ULBP1 in the ER and cis-Golgi, preventing its surface expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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