Thermo Fisher Scientific KCNN1 Polyclonal Antibody
KCNN1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human, Mouse, Rat 시료 반응성이 있으며, Affinity chromatography로 정제되었습니다. 액상 형태로 -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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- PA5114756
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCNN1 (Accession Q92952), corresponding to amino acid residues R390–V440 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899392 |
Product Specific Information
This antibody detects endogenous levels of total KCNN1.
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and influence neuronal firing patterns. Each AHP component is kinetically distinct and mediated by different calcium-activated potassium channels.
The protein encoded by the KCNN1 gene is activated before membrane hyperpolarization and helps regulate neuronal excitability by contributing to the slow component of synaptic AHP. It is an integral membrane protein forming a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN1 belongs to the KCNN family of potassium channels.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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