Thermo Fisher Scientific CD72 Monoclonal Antibody (4G4B1)
CD72 단백질을 인식하는 Mouse Monoclonal Antibody로, Western blot, Flow cytometry, ELISA에 적합합니다. 인간 시료에 반응하며, Protein G로 정제된 Liquid 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G4B1 |
| Immunogen | Purified recombinant fragment of human CD72 (aa 117–359) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898402 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
CD72 is a transmembrane glycoprotein expressed as a homodimer, primarily in B cells and other antigen-presenting cells such as dendritic cells and macrophages. Through its immunoreceptor tyrosine-based inhibitory motifs (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72, leading to dissociation of SHP-1 and enabling B cell activation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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