Thermo Fisher Scientific uPAR Monoclonal Antibody (1D1B11)
인간 uPAR(CD87)에 특이적인 Mouse IgG2b 단클론 항체로, WB, Flow Cytometry, ELISA에 적합합니다. 정제된 재조합 CD87 단편(aa 23-305)을 면역원으로 사용했으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D1B11 |
| Immunogen | Purified recombinant fragment of human CD87 (aa: 23–305) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898403 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes.
Human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes, anchored to the plasma membrane by a glycosyl-phosphatidylinositol linkage.
PLAUR (uPAR) is associated with the carbohydrate-binding domain of SELL on neutrophil membranes, analogous to its association with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent.
UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced stages compared with normal tissue. UPAR protein expression correlates positively with recurrence and mortality rates in endometrial cancer patients, making it a useful prognostic marker for advanced disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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