Thermo Fisher Scientific CD46 Monoclonal Antibody (5A8C11)
인간 CD46 단백질을 인식하는 Mouse IgG1 단클론 항체. Western blot, ICC/IF, Flow cytometry, ELISA에 적합. 단백질 G로 정제된 액상 형태로 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5A8C11 |
| Immunogen | Purified recombinant fragment of human CD46 (aa: extra 35–179) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898400 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments. It regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction.
CD46 also serves as a receptor for several human pathogens (bacteria and viruses), and its ligation alters T lymphocyte polarization toward antigen-presenting or target cells, inhibiting lymphocyte function.
CD46 protects placental tissue and is expressed on the inner acrosomal membrane of spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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