Thermo Fisher Scientific ASAP1 Polyclonal Antibody
ASAP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로 WB 및 ICC/IF에 사용 가능. 높은 특이성과 재현성을 제공하며, 다양한 조직에서 ASAP1 발현 연구에 적합. 연구용으로만 사용.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH, corresponding to residues 962–978 of mouse Centaurin beta 4 (ASAP1). The peptide sequence is identical in mouse. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2058883 |
Product Specific Information
- Recommended positive controls: rat brain, mouse brain, NIH3T3
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
Target Information
ASAP1, also known as Development and differentiation enhancing factor 1, is a protein with two ANK repeats, an Arf-GAP domain, a PH domain, and a SH3 domain.
ASAP1 is a homodimer known to interact with SRC and CRK, and its activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2).
It possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 and ARF5, with lesser activity towards ARF6.
ASAP1 may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2.
It may function as a signal transduction protein involved in fibroblast differentiation into adipocytes and other cell types.
Widely expressed in most tissues, ASAP1 is a proto-oncogene involved in invasive breast cancer and other malignant tumors such as uveal melanomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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