Thermo Fisher Scientific ASAP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

• Recommended positive controls: rat brain, mouse brain, NIH3T3
• Store product as a concentrated solution
• Centrifuge briefly prior to opening the vial

Target Information

ASAP1, also known as Development and differentiation enhancing factor 1, is a protein with two ANK repeats, an Arf-GAP domain, a PH domain, and a SH3 domain.
ASAP1 is a homodimer known to interact with SRC and CRK, and its activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2).
It possesses phosphatidylinositol 4,5-biphosphate-dependent GTPase-activating protein activity for ARF1 and ARF5, with lesser activity towards ARF6.
ASAP1 may coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2.
It may function as a signal transduction protein involved in fibroblast differentiation into adipocytes and other cell types.
Widely expressed in most tissues, ASAP1 is a proto-oncogene involved in invasive breast cancer and other malignant tumors such as uveal melanomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.