Thermo Fisher Scientific NIK Polyclonal Antibody
Thermo Fisher Scientific의 NIK Polyclonal Antibody는 인간 및 마우스 시료에서 MAP3K14 단백질 검출에 적합한 Rabbit IgG 항체입니다. Western blot에 최적화되어 있으며 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA527713
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–213 of Human NIK (UniProt ID: Q99558-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1 M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2545189 |
Product Specific Information
- Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji
- Predicted reactivity: Mouse (91%), Rat (93%), Rhesus Monkey (100%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKα) and IKBKB (IKKβ), which in turn phosphorylate IκB-α, releasing NF-κB and leading to up-regulation of inflammatory response genes.
This kinase binds to TRAF2 and stimulates NF-κB activity. It shares sequence similarity with several other MAPKK kinases and participates in an NF-κB-inducing signaling cascade common to receptors of the TNF/NGF family and the interleukin-1 type-I receptor.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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