Thermo Fisher Scientific NIK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji
• Predicted reactivity: Mouse (91%), Rat (93%), Rhesus Monkey (100%), Bovine (96%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKα) and IKBKB (IKKβ), which in turn phosphorylate IκB-α, releasing NF-κB and leading to up-regulation of inflammatory response genes.
This kinase binds to TRAF2 and stimulates NF-κB activity. It shares sequence similarity with several other MAPKK kinases and participates in an NF-κB-inducing signaling cascade common to receptors of the TNF/NGF family and the interleukin-1 type-I receptor.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.